15.1% Average Loss With Oral Semaglutide at 68 Weeks

OASIS 1 found oral semaglutide 50 mg led to 15.1% average weight loss at 68 weeks in adults without type 2 diabetes, with study context and limits.

At week 68, estimated mean body-weight change was −15.1% with oral semaglutide 50 mg and −2.4% with placebo.

667 adults without type 2 diabetes who had obesity, or overweight plus a weight-related complication; 68 weeks. Read the linked peer-reviewed source for the full methodology, findings, and limitations.

Knop et al., Lancet 2023 · OASIS 1