16.0% Average Loss With Semaglutide Plus Intensive Behavioral Therapy
STEP 3 found semaglutide plus a low-calorie meal-replacement diet and intensive behavioral therapy led to 16.0% average loss at 68 weeks, with study limits.
At week 68, mean body-weight change was −16.0% with semaglutide and −5.7% with placebo, with both groups receiving the intensive lifestyle program.
611 adults without diabetes who had obesity, or overweight plus at least one weight-related comorbidity; 68 weeks. Read the linked peer-reviewed source for the full methodology, findings, and limitations.