Tirzepatide Sleep Apnea Study Results | RxNotebook

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AHI changed by −25.3 versus −5.3 events per hour in the trial without PAP at baseline, a −20.0-event-per-hour difference; the corresponding difference in the PAP trial was −23.8 events per hour.

Adults with moderate-to-severe obstructive sleep apnea and obesity; one trial enrolled people not using PAP and one enrolled people using PAP; 52 weeks. Read the linked peer-reviewed source for the full methodology, findings, and limitations.

Malhotra et al., NEJM 2024 · SURMOUNT-OSA