13.7% Average Loss With Semaglutide in Knee Osteoarthritis
STEP 9 found semaglutide led to 13.7% average weight loss and improved knee-pain scores at 68 weeks in adults with obesity and knee osteoarthritis.
At week 68, mean body-weight change was −13.7% with semaglutide and −3.2% with placebo; WOMAC knee-pain score change was −41.7 and −27.5 points, respectively.
407 adults with obesity, moderate clinical and radiographic knee osteoarthritis, and at least moderate knee pain; 68 weeks. Read the linked peer-reviewed source for the full methodology, findings, and limitations.