§ Hormones & TRT
Estradiol (in TRT)
An estrogen produced when testosterone is aromatized; monitored on TRT to manage side effects.
Fact-checked 12 May 2026Plain-English Reference
Some testosterone is converted to estradiol via the aromatase enzyme. Mildly elevated estradiol on TRT is normal and often beneficial; significantly elevated estradiol can contribute to gynecomastia, water retention, or mood changes. Aromatase inhibitors (e.g., anastrozole) are used selectively, not universally.