§ GLP-1 & Weight Loss
STEP 1
The pivotal RCT of semaglutide 2.4 mg for weight management (NEJM, 2021). Participants lost 14.9% body weight over 68 weeks versus 2.4% with placebo.
Fact-checked 12 May 2026Plain-English Reference
STEP 1 was a 68-week, double-blind randomized trial of 1,961 adults with overweight or obesity (without diabetes). Participants on semaglutide 2.4 mg lost an average 14.9% of body weight versus 2.4% on placebo. STEP 1 is the basis for Wegovy's FDA approval.
§ Where STEP 1 Comes Up
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