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§ Brand Review · Erectile Dysfunction

QUAD by MEDVi Review

4-in-1 sublingual ED liquid combining four prescription mechanisms in a single rapid-absorb dose.

Last reviewed August 2026
4 studies cited
Fact-checked 12 August 2026Last updated 15 June 2026From $12 – $199/moEditor Score 4.3 / 5Trustpilot 4.3 · Great

Reader-supported, we may earn a commission through links on this site. Rankings are editorially independent. Disclosure · Methodology

Quick Verdict

4-in-1 sublingual ED liquid combining four prescription mechanisms in a single rapid-absorb dose.

Who it's for: QUAD is the right choice for men who have tried standard sildenafil or tadalafil and want a faster-acting alternative, or who want to try a multi-mechanism approach. The sublingual format bypasses the stomach for quicker onset. Not suitable for men on nitrates or with certain cardiovascular conditions. clinician review required.

Bottom line: The most differentiated ED product on this site. If you've tried the standard pills and want something with a faster onset and a broader pharmacological profile, QUAD is worth a clinician consultation. The $12/dose price is competitive for a prescription product.

Pros
  • 4-in-1 formula covers multiple ED mechanisms in one dose
  • Sublingual absorption. faster onset than oral tablets
  • No monthly subscription. pay per dose
  • Clinician-prescribed with MEDVi's established telehealth infrastructure
Cons
  • Contains apomorphine, not suitable for all patients (contraindicated with nitrates)
  • Newer product with limited long-term outcome data
  • ED-only, no broader men's health coverage

Pros & Cons In Detail

4-in-1 formula covers multiple ED mechanisms in one dose
In practice this is one of the differentiators that pushes QUAD by MEDVi's editor score above the category median.
Sublingual absorption. faster onset than oral tablets
In practice this is one of the differentiators that pushes QUAD by MEDVi's editor score above the category median.
No monthly subscription. pay per dose
In practice this is one of the differentiators that pushes QUAD by MEDVi's editor score above the category median.
Clinician-prescribed with MEDVi's established telehealth infrastructure
Active clinical oversight means dose changes, side-effect management, and labs are handled by a licensed prescriber rather than a generic intake form.
Contains apomorphine, not suitable for all patients (contraindicated with nitrates)
It's a real trade-off worth knowing about before you commit, even if it isn't a deal-breaker on its own.
Newer product with limited long-term outcome data
It's a real trade-off worth knowing about before you commit, even if it isn't a deal-breaker on its own.
ED-only, no broader men's health coverage
It's a real trade-off worth knowing about before you commit, even if it isn't a deal-breaker on its own.

QUAD by MEDVi Pricing

Telehealth ads often advertise a low headline price that's the clinic's program fee, not the medication. Here's how the two line items break down at QUAD by MEDVi.

Program / Membership FeeNo subscription required
Medication Cost (From)From $12 – $199/mo
What This Means For You

QUAD is priced per dose at $12, with no monthly subscription required. The sublingual liquid dissolves under the tongue, bypassing the digestive system for faster absorption than standard oral ED pills.

Who QUAD by MEDVi Is For

QUAD is the right choice for men who have tried standard sildenafil or tadalafil and want a faster-acting alternative, or who want to try a multi-mechanism approach. The sublingual format bypasses the stomach for quicker onset. Not suitable for men on nitrates or with certain cardiovascular conditions. clinician review required.

How QUAD by MEDVi Markets Itself

Men who have tried standard ED medications and want a faster-acting, multi-mechanism alternative.

Signature Programs

  • ›QUAD 4-in-1 sublingual liquid (Sildenafil + Tadalafil + Vardenafil + Apomorphine)

Medication Formulary

Full Formulary
sildenafiltadalafilvardenafilapomorphine

The Bottom Line

The most differentiated ED product on this site. If you've tried the standard pills and want something with a faster onset and a broader pharmacological profile, QUAD is worth a clinician consultation. The $12/dose price is competitive for a prescription product.

With an editor score of 4.3 / 5 across cost, experience, and trust, QUAD by MEDVi is one of the strong mid-tier options in the erectile dysfunction category we cover.

See how QUAD by MEDVi compares in our full erectile dysfunction rankings, or read the Best ED Treatments You Can Get Online in 2026 guide. Our methodology explains how we score each provider.

§ FAQ

Frequently Asked Questions

References
  1. Goldstein et al., NEJM 1998 (Sildenafil) · Pivotal NEJM trial establishing sildenafil efficacy: 69% of attempts successful vs 22% placebo.
  2. Brock et al., J Urol 2002 (Tadalafil) · Tadalafil 20 mg showed 75% successful intercourse attempts vs 32% placebo in pivotal Phase III trial.
  3. Bhasin et al., J Clin Endocrinol Metab 2018 (Endocrine Society TRT guideline) · Endocrine Society clinical practice guideline recommends testosterone therapy for men with symptomatic hypogonadism confirmed by low serum testosterone on two morning measurements.
  4. FDA Prescribing Information: testosterone cypionate injection · FDA-approved prescribing information for testosterone cypionate injection, including dosing, REMS requirements, and cardiovascular risk warnings.

RxNotebook is an editorial publication. Citations point to peer-reviewed journals, FDA labeling, and clinical society guidelines. We are not affiliated with the studies cited above. This page is for general information and is not medical advice.

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