Buy Sildenafil Online in 2026 — Verified Providers
Sildenafil (the generic of Viagra) is the most-prescribed PDE5 inhibitor. Telehealth providers offer everything from generic tablets to rapid-dissolve sublingual formulations.
A PDE5 inhibitor that increases blood flow to the penis to support erection in response to sexual stimulation.
Adult men with erectile dysfunction without contraindications such as nitrate use.
Generic sildenafil pricing typically $1-$3 per dose. Compounded sublingual formats range higher.
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What the Studies Actually Show
Sildenafil (the active ingredient in Viagra) is the most-studied PDE5 inhibitor. The figures below come from the pivotal RCT and the FDA prescribing information.
| Endpoint | Finding |
|---|---|
| Efficacy (Goldstein et al., pivotal RCT)1 | 69% of attempts at intercourse successful with sildenafil 50–100 mg vs 22% with placebo in men with ED |
| Onset & duration2 | Onset 30–60 minutes; clinically meaningful effect for ~4 hours; high-fat meal can delay absorption |
| Common side effects (FDA prescribing information)2 | Headache 16%, flushing 10%, dyspepsia 7%, nasal congestion 4%, abnormal vision 3% |
| Contraindications2 | Concurrent use of any nitrate (chest pain medications) is absolutely contraindicated due to risk of severe hypotension. Caution with alpha-blockers and CYP3A4 inhibitors |
- Goldstein I et al. — NEJM 1998 · Goldstein I, Lue TF, Padma-Nathan H, et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998;338:1397–1404.
- FDA Prescribing Information — Viagra (sildenafil) · VIAGRA (sildenafil citrate) tablets. U.S. Food and Drug Administration prescribing information.
RxNotebook is an editorial publication. Citations point to peer-reviewed journals, FDA labeling, and clinical society guidelines. We are not affiliated with the studies cited above. This page is for general information and is not medical advice.