Compounded Semaglutide Online — 2026 Provider Comparison
Compounded semaglutide is dispensed by state-licensed compounding pharmacies and prescribed by licensed clinicians. It is typically less expensive than brand-name Wegovy and is available in injectable, oral-dissolving, and sublingual formats.
Compounded semaglutide contains the same active ingredient as Wegovy and Ozempic but is custom-mixed by a compounding pharmacy. Some formulations include B12 or other adjuncts.
Adults seeking semaglutide weight loss support who prefer the cost flexibility and dose customization that compounded formulations allow.
Pricing typically ranges from $150 to $300 per month. Most platforms use telehealth intake, mailed test kits, and direct pharmacy fulfillment.
Rankings combine clinical formulary depth, pricing transparency, and shipping reliability — weighted equally and reviewed quarterly. Read the full methodology →
Providers That Prescribe compounded
Personalized clinical weight loss with state-licensed pharmacy fulfillment and an unusually low program entry price.
Mainstream telehealth giant with FDA-approved GLP-1s, an insurance concierge, and prepay savings.
Affordable subscription telehealth with one of the largest compounded formularies in the industry.
Broad-catalog telehealth covering hair, skin, weight loss, and sexual health, with free shipping and follow-ups bundled in.
Flat-rate compounded GLP-1s plus brand-name Wegovy and Zepbound, with all dosages priced the same.
Full-spectrum GLP-1 program with both compounded and brand-name access plus unlimited provider check-ins.
Flat upfront pricing with the same dose-equal cost across both compounded and brand-name GLP-1s.
Publicly traded telehealth giant with weight-loss, ED, and hair-loss programs under one roof.
Asynchronous sexual and reproductive healthcare for women across every life stage.
Personalised, physician-endorsed longevity and weight-loss therapies, fully online.
Yucca Health
Provider-guided care from US-licensed pharmacies, covering GLP-1, NAD+, and recovery-focused peptides.
Affordable men's health clinic specialised in TRT and weight loss with transparent pricing.
Women-focused sister brand to Hims spanning GLP-1, hair, skincare, and menopause care.
Embody
Flexible, medically guided compounded GLP-1 weight loss with transparent monthly pricing.
Cash-pay telehealth marketplace with transparent per-visit pricing and Costco-member discounts.
Online doctor's office and pharmacy with 48-hour delivery and no required virtual visit in most states.
Wellorithm
Focused compounded GLP-1 clinic with 24/7 support and a single transparent monthly price.
Doctor-guided GLP-1 program with both injectable and tablet options across multiple categories.
Sprout Health
Compounded GLP-1 plus NAD+ therapy with transparent flat-rate pricing and fast shipping.
Clinician-guided GLP-1 platform with both compounded and brand-name access plus overnight shipping.
Provider-guided metabolic, cellular, and sexual performance protocols designed for people who train.
Longevity-first clinic that bundles GLP-1, peptides, and enclomiphene into one healthspan program.
GLP-1 clinic with rare oral and sublingual delivery options and a NAD+ longevity layer.
Sermorelin-led peptide clinic that also covers GLP-1, NAD+, and brand-name Zepbound.
Wide compounded and brand-name catalog covering weight loss, anti-aging, and hair growth without insurance.
Compounded GLP-1 clinic with transparent pricing and dedicated nurse support.
Compounded GLP-1 plus NAD+ and sermorelin longevity protocols under one membership.
Gala Health
Women-focused telehealth combining compounded GLP-1 weight loss with HRT support.
Personalised GLP-1 and sexual-wellness program with insurance navigation and optional nutrition coaching.
LIV Body
Flat-rate compounded GLP-1 program from a fitness-led brand with 24/7 clinical support.
Novi
Compounded-only GLP-1 platform with 50,000+ patients, free 2-day shipping, and no contracts.
Lab-driven telehealth clinic combining GLP-1, TRT, BHRT, and peptide longevity protocols.
GLP-1 platform that pairs medication with one-on-one coaching and a broad off-label formulary.
Medically supervised, discreet, multi-category telehealth with a heavy compounded formulary.
Custom-compounded, rapid-dissolve treatments for men's health with transparent pricing and free provider visits.
Sunlight
Cancel-anytime compounded GLP-1 clinic with free shipping and no long-term commitment.
GLP-1 clinic offering injections, oral semaglutide, drops, and lozenges plus brand-name Wegovy and Zepbound.
Affordable compounded GLP-1 with no hidden membership fees, plus longevity peptides.
GLP-1 weight-loss platform combined with personalised nutrition and fitness coaching.
Willow
Premium GLP-1 clinic with a needle-free sublingual semaglutide tablet option.
Enhance.MD
Provider-led metabolic and NAD+ wellness platform with transparent flat pricing.
What the Studies Actually Show
Compounded semaglutide contains the same active ingredient as Wegovy and Ozempic. There are no randomized trials of compounded formulations themselves; efficacy is inferred from the trials of the underlying API and from the FDA prescribing information for the brand-name product.
| Endpoint | Finding |
|---|---|
| Mean weight loss (STEP 1, 68 weeks, 2.4 mg)1 | −14.9% body weight vs −2.4% placebo in adults with overweight/obesity without diabetes |
| Cardiovascular outcomes (SELECT, ~40 months)2 | 20% relative risk reduction in major adverse cardiovascular events (MACE) in adults with established CV disease and overweight/obesity |
| GI side effects (FDA prescribing information)3 | Nausea ≥10%, diarrhea ≥10%, vomiting ≥10%, constipation ≥10%; most cases mild–moderate and dose-dependent |
| Boxed warning3 | Risk of thyroid C-cell tumors observed in rodent studies; contraindicated in personal/family history of MTC or MEN 2 |
| A1C reduction (T2D, SUSTAIN program)4 | ≈1.4–1.8% A1C reduction at 1.0 mg weekly across SUSTAIN-2 through SUSTAIN-7 head-to-head trials |
| Compounded semaglutide — evidence basis5 | Active ingredient is identical to Wegovy/Ozempic; efficacy is inferred from the active ingredient. The FDA does not formally approve compounded products; quality depends on the 503A/503B compounding pharmacy Following the FDA's 2024 ruling that ended the official tirzepatide and semaglutide shortages, compounded GLP-1s are dispensed under the personalisation exception, which requires a documented clinical justification (custom dose, B12 addition, or documented intolerance to an inactive ingredient). |
Frequently Asked Questions
Is compounded semaglutide legal?
Yes, when prescribed by a licensed clinician and dispensed by a state-licensed compounding pharmacy. The FDA periodically updates guidance, so always verify the pharmacy's current licensure status.
- STEP 1 — NEJM 2021 · Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med 2021;384:989–1002.
- SELECT — NEJM 2023 · Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med 2023;389:2221–2232.
- FDA Prescribing Information — Wegovy (semaglutide) · WEGOVY (semaglutide) injection, for subcutaneous use. U.S. Food and Drug Administration prescribing information.
- SUSTAIN program — ADA scientific summary · Aroda VR, Ahmann A, Cariou B, et al. Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1–7 clinical trials. Diabetes Obes Metab 2019;21(7):1601–1613.
- FDA — Compounding and the FDA: Questions and Answers · U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers (last updated 2024).
RxNotebook is an editorial publication. Citations point to peer-reviewed journals, FDA labeling, and clinical society guidelines. We are not affiliated with the studies cited above. This page is for general information and is not medical advice.