Compounded Tirzepatide Online — 2026 Provider Comparison
Compounded tirzepatide offers a lower-cost alternative to brand-name Zepbound and Mounjaro. It is available via licensed compounding pharmacies in injectable, oral-dissolving, and sublingual formulations.
Compounded tirzepatide contains the same active ingredient as Zepbound and Mounjaro but is custom-mixed by a compounding pharmacy.
Adults seeking dual GIP/GLP-1 receptor agonist therapy who prefer compounded pricing and dose customization.
Pricing typically ranges from $200 to $400 per month depending on dose and frequency.
Rankings combine clinical formulary depth, pricing transparency, and shipping reliability — weighted equally and reviewed quarterly. Read the full methodology →
Providers That Prescribe compounded
Personalized clinical weight loss with state-licensed pharmacy fulfillment and an unusually low program entry price.
Affordable subscription telehealth with one of the largest compounded formularies in the industry.
Broad-catalog telehealth covering hair, skin, weight loss, and sexual health, with free shipping and follow-ups bundled in.
Flat-rate compounded GLP-1s plus brand-name Wegovy and Zepbound, with all dosages priced the same.
Full-spectrum GLP-1 program with both compounded and brand-name access plus unlimited provider check-ins.
Flat upfront pricing with the same dose-equal cost across both compounded and brand-name GLP-1s.
Personalised, physician-endorsed longevity and weight-loss therapies, fully online.
Yucca Health
Provider-guided care from US-licensed pharmacies, covering GLP-1, NAD+, and recovery-focused peptides.
Affordable men's health clinic specialised in TRT and weight loss with transparent pricing.
Women-focused sister brand to Hims spanning GLP-1, hair, skincare, and menopause care.
Embody
Flexible, medically guided compounded GLP-1 weight loss with transparent monthly pricing.
Online doctor's office and pharmacy with 48-hour delivery and no required virtual visit in most states.
Wellorithm
Focused compounded GLP-1 clinic with 24/7 support and a single transparent monthly price.
Sprout Health
Compounded GLP-1 plus NAD+ therapy with transparent flat-rate pricing and fast shipping.
Clinician-guided GLP-1 platform with both compounded and brand-name access plus overnight shipping.
Provider-guided metabolic, cellular, and sexual performance protocols designed for people who train.
Longevity-first clinic that bundles GLP-1, peptides, and enclomiphene into one healthspan program.
GLP-1 clinic with rare oral and sublingual delivery options and a NAD+ longevity layer.
Sermorelin-led peptide clinic that also covers GLP-1, NAD+, and brand-name Zepbound.
Wide compounded and brand-name catalog covering weight loss, anti-aging, and hair growth without insurance.
Compounded GLP-1 clinic with transparent pricing and dedicated nurse support.
Compounded GLP-1 plus NAD+ and sermorelin longevity protocols under one membership.
Gala Health
Women-focused telehealth combining compounded GLP-1 weight loss with HRT support.
Personalised GLP-1 and sexual-wellness program with insurance navigation and optional nutrition coaching.
LIV Body
Flat-rate compounded GLP-1 program from a fitness-led brand with 24/7 clinical support.
Novi
Compounded-only GLP-1 platform with 50,000+ patients, free 2-day shipping, and no contracts.
Lab-driven telehealth clinic combining GLP-1, TRT, BHRT, and peptide longevity protocols.
GLP-1 platform that pairs medication with one-on-one coaching and a broad off-label formulary.
Medically supervised, discreet, multi-category telehealth with a heavy compounded formulary.
Sunlight
Cancel-anytime compounded GLP-1 clinic with free shipping and no long-term commitment.
GLP-1 clinic offering injections, oral semaglutide, drops, and lozenges plus brand-name Wegovy and Zepbound.
Affordable compounded GLP-1 with no hidden membership fees, plus longevity peptides.
Willow
Premium GLP-1 clinic with a needle-free sublingual semaglutide tablet option.
Enhance.MD
Provider-led metabolic and NAD+ wellness platform with transparent flat pricing.
What the Studies Actually Show
Compounded tirzepatide contains the same active ingredient as Zepbound and Mounjaro. There are no randomized trials of compounded formulations themselves; efficacy is inferred from the trials of the underlying API and from the FDA prescribing information for the brand-name product.
| Endpoint | Finding |
|---|---|
| Mean weight loss (SURMOUNT-1, 72 weeks, 15 mg)1 | −20.9% body weight vs −3.1% placebo in adults with obesity without diabetes |
| Mean weight loss with T2D (SURMOUNT-2, 72 weeks, 15 mg)2 | −14.7% body weight in adults with type 2 diabetes |
| Sleep apnea (SURMOUNT-OSA)3 | Tirzepatide reduced apnea-hypopnea index (AHI) by ~25–29 events/hour vs placebo at 52 weeks; FDA-approved labeling for moderate-to-severe OSA in obesity |
| GI side effects (FDA prescribing information)4 | Nausea ≥10%, diarrhea ≥10%, vomiting ≥5%, constipation ≥5% |
| Boxed warning4 | Risk of thyroid C-cell tumors observed in rodent studies; contraindicated in personal/family history of MTC or MEN 2 |
| A1C reduction (T2D, SURPASS program)5 | ≈1.9–2.4% A1C reduction at 15 mg weekly across SURPASS-1 through SURPASS-5 |
| Compounded tirzepatide — evidence basis6 | Active ingredient is identical to Zepbound/Mounjaro; efficacy is inferred from the active ingredient. FDA does not formally approve compounded products |
Frequently Asked Questions
Is compounded tirzepatide as effective as Zepbound?
Compounded tirzepatide contains the same active ingredient. Effectiveness depends on dose, adherence, and formulation quality from the compounding pharmacy.
- SURMOUNT-1 — NEJM 2022 · Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med 2022;387:205–216.
- SURMOUNT-2 — Lancet 2023 · Garvey WT, Frias JP, Jastreboff AM, et al. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 2023;402(10402):613–626.
- SURMOUNT-OSA — NEJM 2024 · Malhotra A, Grunstein RR, Fietze I, et al. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity. N Engl J Med 2024;391:1193–1205.
- FDA Prescribing Information — Zepbound (tirzepatide) · ZEPBOUND (tirzepatide) injection, for subcutaneous use. U.S. Food and Drug Administration prescribing information.
- SURPASS — program summary · Frias JP, Davies MJ, Rosenstock J, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2). N Engl J Med 2021;385:503–515.
- FDA — Compounding and the FDA: Questions and Answers · U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers (last updated 2024).
RxNotebook is an editorial publication. Citations point to peer-reviewed journals, FDA labeling, and clinical society guidelines. We are not affiliated with the studies cited above. This page is for general information and is not medical advice.